Diphenhydramine is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side effect. 5. Tips. Diphenhydramine may be taken with or without food. Take exactly as directed.. Common side effects of Allergy (Diphenhydramine HCl) may include: drowsiness; dry eyes, blurred vision; dry mouth, nose, or throat; decreased urination; constipation; feeling restless or excited (especially in children); or. day-time drowsiness or "hangover" feeling after night-time use. This is not a complete list of side effects and others.
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Diphenhydramine is a first-generation antihistamine — see below for a list of products that contain diphenhydramine. You should not use first-generation antihistamines for the treatment of cough, cold and flu symptoms in children under 6 years. You should not give first-generation antihistamines to children under 2 years for any reason.. An unusual or allergic reaction to diphenhydramine, other medications, foods, dyes, or preservatives; Pregnant or trying to get pregnant; Breast-feeding;. Do not use this medication on large areas of the body or with other products that contain diphenhydramine. To do so may increase the risk of side effects. Do not get this medication in.